DCDC2, KIAA0319 and CMIP Are Associated with Reading-Related Traits
نویسندگان
چکیده
منابع مشابه
DCDC2, KIAA0319 and CMIP Are Associated with Reading-Related Traits
BACKGROUND Several susceptibility genes have been proposed for dyslexia (reading disability; RD) and specific language impairment (SLI). RD and SLI show comorbidity, but it is unclear whether a common genetic component is shared. METHODS We have investigated whether candidate genes for RD and SLI affect specific cognitive traits or have broad effect on cognition. We have analyzed common risk ...
متن کاملInvestigation of Dyslexia and SLI Risk Variants in Reading- and Language-Impaired Subjects
Dyslexia (or reading disability) and specific language impairment (or SLI) are common childhood disorders that show considerable co-morbidity and diagnostic overlaps and have been suggested to share some genetic aetiology. Recently, genetic risk variants have been identified for SLI and dyslexia enabling the direct evaluation of possible shared genetic influences between these disorders. In thi...
متن کاملDCDC2 is associated with reading disability and modulates neuronal development in the brain.
DYX2 on 6p22 is the most replicated reading disability (RD) locus. By saturating a previously identified peak of association with single nucleotide polymorphism markers, we identified a large polymorphic deletion that encodes tandem repeats of putative brain-related transcription factor binding sites in intron 2 of DCDC2. Alleles of this compound repeat are in significant disequilibrium with mu...
متن کاملThree dyslexia susceptibility genes, DYX1C1, DCDC2, and KIAA0319, affect temporo-parietal white matter structure.
BACKGROUND Volume and integrity of white matter correlate with reading ability, but the underlying factors contributing to this variability are unknown. METHODS We investigated single nucleotide polymorphisms in three genes previously associated with dyslexia and implicated in neuronal migration (DYX1C1, DCDC2, KIAA0319) and white matter volume in a cohort of 76 children and young adults from...
متن کاملThe KIAA0319 Gene Polymorphisms are Associated with Developmental Dyslexia in Chinese Uyghur Children Association of KIAA0319 Polymorphisms with Developmental Dyslexia
To investigate the association of KIAA0319 gene polymorphisms and developmental dyslexia in individuals of Uyghurian descent. Eighteen single nucleotide polymorphisms (SNP) of gene KIAA0319 were screened in a group of 196 patients with dyslexia and 196 controls of Uyghur descent by determined the genotypes using a custom-by-design 48-Plex SNPscanTM Kit. SAS 9.1.3 software were used for data ana...
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ژورنال
عنوان ژورنال: Biological Psychiatry
سال: 2011
ISSN: 0006-3223
DOI: 10.1016/j.biopsych.2011.02.005